We know what you’re thinking. Governments experimenting on their own people? That is just science fiction, and could never be real-life. Contrary to what some might want to believe, several governments have done this. In fact, several governments conducted experiments on their own people more than they have on enemies of the state. This goes back to ancient times too when places like Greece and China used to experiment on prisoners. Most of which were citizens of their nation.
It’s a bit odd to consider for many. Why would governments want to do this? Moreover, why would they choose to do extreme testing that could be a huge issue for those in their nation? It would only result in population decline. While many nations have conducted experiments on their own, we will mostly be discussing America. The reason for this is specifically due to the Freedom of Information Act, which allows Americans to know about past government exploits. Let’s discuss these government experiments!

Dietary Deficiencies With Racial Ties
- Year(s) Conducted: Mid-1930s
- Nation Involved: The United States of America
America has a dark past, filled with terrible actions against African-American men and women. However, one issue that might bother many is both their inaction and idiotic reaction to things. This specifically has to do with something known as “Pellagra,” a dietary deficiency. It often affects poverty-stricken areas, but in America, it often affected black populations. This was due to the high level of poverty they experienced in the early 1900s. Dr. Joseph Goldberger, a physician in the U.S. government’s Hygienic Laboratory, discovered how it kept killing off many people across the nation.


Stateville Penitentiary Malaria Study
- Year(s) Conducted: Mid-1940s
- Nation Involved: The United States of America
It might seem odd, but for centuries there have been scientists that decided to conduct tests on prisoners. The idea was that they were considered bad people for breaking the law. There is a lot wrong with that, but several prisons have been involved in these studies. Some act alone or with a university/scientist. Yet they are also areas where governments conducted experiments on their own people quite often.


North Korean Poison Cabbage Experiment
- Year(s) Conducted: Somewhere Between 1986 & 1992
- Nation Involved: North Korea
While it is not exactly certain about a specific time period, we do know that North Korea has experimented on its people for many years. We began discussing it far more thanks to three people. Kwon Hyok & Ahn Myung Chul, two former prison guards in NK. As well as a former prisoner there, Lee Soon-ok. Lee wrote about a lot of the things she saw or personally experienced in her book, Eyes of the Tailless Animals, published in 1999.


The Dioxin Experiments
- Year(s) Conducted: 1960s
- Nation Involved: The United States of America
During the Vietnam War, the U.S. began using a biological weapon known as Agent Orange. Yet they worried about the long-term effects. Dr. Albert Kligman was given a $10,000 grant to study numerous chemicals on behalf of Dow Corning, Johnson & Johnson, and of course, the U.S. Army. They wanted to see how human skin reacted to harsh chemicals, which they referred to as “hardening.” They had him test many things, but hidden in the chemicals to test was Dioxin (the main ingredient in Agent Orange). In 1981, six years after the Vietnam War ended, all of his notes were said to have been destroyed.


Twin-Triplet Separation Experiment
- Year(s) Conducted: 1960s to 1970s
- Nation Involved: The United States of America
A group of psychologists ran a secret experiment on twins & triplet children between the 1960s & 1970s. They began separating them at birth from their siblings and having them adopted as single children without their brothers or sisters. The adoptive parents were never told their son or daughter had twin or triplet siblings. The United States National Institute of Mental Health partly funded the experiment, which was only found out due to separated brothers finding each other in 1980.


Operation Whitecoat
- Year(s) Conducted: 1954 to 1973
- Nation Involved: The United States of America
During the Cold War, while some people signed up to be part of the U.S. Armed Forces, others were drafted. Most people knew if you were going to be involved in the military, especially during global conflict, you might have to kill someone. This was a problem for some men who were drafted, specifically the Seventh-Day Adventists. This denomination in Christianity takes the Bible very seriously, especially the part that reads “Thou shalt not kill.” This made using them hard for the military.


Cold War British Biological Warfare Toxin Drop
- Year(s) Conducted: 1953 to 1964
- Nation Involved: The United Kingdom
The Cold War was not just a problematic time for the United States, as the United Kingdom also made boneheaded decisions during that period. Apparently, the Brits dropped thousands of kilos of an unknown, potentially toxic chemical out of a military aircraft. They’d do this right over their own civilian population in and around Wiltshire, Bedfordshire, & Norfolk. Some were even dropped across parts of the English Channel & the North Sea.


Operation Drop Kick
- Year(s) Conducted: 1956 & 1957
- Nation Involved: The United States of America
While the U.S. Army is known for conducting biowarfare experiments, this could have gone very bad for them. In 1956 & 1957, they conducted experiments on the cities of Avon Park, FL & Savannah, GA. As we know, when governments conducted experiments on their own people, they do not stop with one experiment. The Army did many on people in these cities, but one takes the cake. It is referred to as Operation Drop Kick. Why? We haven’t a clue.


Project MK-Ultra
- Year(s) Conducted: 1953 to 1973
- Nation Involved: The United States of America
The United States Government has been obsessed with learning about mind control & brainwashing. While such concepts do not actually exist, we do know one can affect the mind through suggestion and hypnotic techniques. This is often used by magicians, but the government did not consider asking them anything. Instead, they tried out drugs that could potentially alter the mind. This happened with Project MK-Ultra, a CIA-sponsored venture that was conducted on unwilling American citizens.


America’s Human Plutonium Injection Experiments
- Year(s) Conducted: 1945 to 1947
- Nation Involved: The United States of America
The United States was forced to create the first atomic bomb in an effort to beat other nations to nuclear weapons. The idea was that this specific weapon would be essential to helping America remain a superpower in the world. Yet many scientists realized problems could occur when they are dropped, beyond the obvious destruction. Specifically, they wanted to find out at this point what the hazards of plutonium were. Government scientists began their research into this on April 10, 1945.


Soviet Union Poison Experiments
- Year(s) Conducted: 1921 to 1970s (Reactivated In The 1990s By Russia)
- Nation Involved: Soviet Union/Russia
Governments conducted experiments on their own people often to test poison among other biological agents. Yet the nation known for doing this the most is certainly the Soviet Union, and eventually the main nation from the broken union, Russia. It all began in 1921 when the Soviets opened specific poison laboratories which they uniquely named Laboratory 1, Laboratory 12, and Kamera. Most of the experiments they conducted were on prisoners from their infamous Gulags.


Guatemalan Syphilis Experiment
- Year(s) Conducted: 1946 to 1948
- Nation Involved: The United States of America & Guatemala
When governments conducted experiments on their own people in the 1940s, you normally only saw it happen with just one nation. Yet in this situation, two were involved. From 1946 to 1948, American Public Health doctors infected 700 prison inmates, mental patients, and soldiers with STDs. Prisons in Guatemala allow conjugal visits, and thus, many prisoners get it on with a wife or girlfriend. Yet others can have “fun” with a prostitute. The U.S. National Institutes of Health decided to send in prostitutes already infected with syphilis for the prisoners to “get it on” with.


Testicle Radiation Experiment
- Year(s) Conducted: 1963 to 1973
- Nation Involved: The United States of America
Governments conducted experiments on their own people for many reasons, but the United States took things up a notch starting in the 1960s. Several dozens of prisoners from Washington & Oregon were used as test subjects for something most would consider barbaric. The government used them to test the effects of radiation on testicles. Many were bribed with cash as well as the “suggestion” of parole if they took part in the experiment.


Project Artichoke
- Year(s) Conducted: 1950s
- Nation Involved: The United States of America
Did we mention that the United States was obsessed with mind-control stuff during the Cold War era yet? They tested this out in multiple projects over the years. Usually, when governments conducted experiments on their own people in the mind-control realm, they try brain techniques. As in, they want to try hypnosis concepts or even exposure therapy. However, in Project Artichoke, the U.S. did try those things but also used hardcore drugs as well.


Project 112
- Year(s) Conducted: 1963 to Early 1970s
- Nation Involved: The United States of America
During several wars, especially the Cold War, biological weapons were being employed around the world. This became a huge problem, and America wanted to make sure its Armed Forces were capable of surviving them. That led to the Department of Defense starting Project 112. During this experiment, the government sprayed several ships as well as hundreds of Navy sailors with nerve agents. Sarin and VX were among the ones they used.


More British Biowarfare Experiments
- Year(s) Conducted: 1964
- Nation Involved: The United Kingdom
During his investigation, Professor Schmidt also found that the UK used London commuters as test subjects. In fact, while this was sort of known for a bit, Schmidt found out the experiment was done at a far larger scale than previously assumed. It is known that several governments conducted experiments on their own people in the world of transit from the 1910s to the 1970s by now. Of course, it was usually to test how trains, subways, or cars worked for most.


Cancer Infection Experiments
- Year(s) Conducted: 1930s
- Nation Involved: The United States of America
Back in the 1930s, there were tons of odd experiments taking place. Of course, governments experimented on their own people quite often in this era. Some used blood from younger people and inserted it into themselves to make themselves younger, and much more. However, one experiment conducted by the United States involved literally trying to give people cancer! We’re completely serious, people. The Rockefeller Institute for Medical Investigations was responsible for “infecting” human subjects with cancer cells.


The Aversion Project
- Year(s) Conducted: 1969/1970
- Nation Involved: South Africa
South Africa is known for its racist Apartheid Era obviously. While America and other nations have a dark past involving race, South Africa also has a horrible history with other people too. Specifically, their treatment of homosexual people during Apartheid was appalling. While governments experimenting on their own people is a common theme here, it has mostly been about race or class. In this situation, it was all about trying to “cure” homosexuality by force.


Operation Sea-Spray
- Year(s) Conducted: 1950
- Nation Involved: The United States of America
Back in the 1950s, governments conducted experiments on their own people quite often as a sort of “preparedness” test. The idea being that biological warfare was already a thing, and we needed to know how to respond to those issues. If something came to mainland America, how would we respond? The U.S. Government certainly wanted to know the answer. This is why they had the U.S. Navy spray a cloud of bacteria over the city of San Francisco.


Operation Midnight Climax
- Year(s) Conducted: 1955 to 1965
- Nation Involved: The United States of America
Stop us if you’ve heard this before, the U.S. Government wanted to conduct mind-control experiments. This particular experiment, known as Operation Midnight Climax, might be one of the worst though. The experiment was given its name due to the CIA using prostitutes to lure men into places where the CIA would abduct them. They used San Francisco and New York City as the spots they would do this, forcing men to comply with their experiments without their consent.


The Psammetichus Experiment
- Year(s) Conducted: Sometime Between 664 to 610 B.C.
- Nation Involved: Egypt
The Psammetichus Experiment is the oldest known psychological experiment known to history. We know of it due to the story from respected Greek historian, Herodotus. The story goes that the Egyptian Pharaoh Psammetichus I performed an experiment to determine if humans were born with the ability to speak. If so, which specific language is within them to actually use. To find this out, he ordered that two infants be brought up in a remote place by a shepherd.


The Hepatitis B Experiment
- Year(s) Conducted: 1978
- Nation Involved: The United States of America
Back in the 1970s, there were many people who had a problem with the new way young people were acting. It was the “Hippie Period.” Sex, Drugs, and Rock N’ Roll was the mindset for American youth. Yet homosexuality was also becoming a little more accepted than it had been in the years prior. Yet many were still not cool with it, and that included the American government. While sexually transmitted diseases can pass between men and women, they can also pass between two men as well.


Nazi Concentration Camp Experiments
- Year(s) Conducted: 1933 to 1945
- Nation Involved: Germany
When governments conducted experiments on their own people in history up to the early 1900s, it was usually on people society looked down upon. Yet things really changed heavily in Nazi Germany, once Adolph Hitler took power and rounded up Jewish people. He blamed all the nation’s problems on them when there were many problems often unrelated to the Jews. In spite of this, over 6 million Jewish people were rounded up and put into Concentration Camps.


Mustard Gas Experiments
- Year(s) Conducted: 1940s
- Nation Involved: The United States of America
At some point in 1943, the United States Navy decided it wanted to expose its sailors to mustard gas. The official experiment was supposed to test the effectiveness of new clothing and gas masks. Since the gas was so damaging during World War I, it made sense to want to find ways to battle it. This led them to conduct experiments at the Naval Research Laboratory in Washington. The Navy recruited thousands of 17 & 18-year-old boys that were all roughly eight weeks into boot camp.


Tuskegee Syphilis Study
- Year(s) Conducted: 1932 to 1972
- Nation Involved: The United States of America
Possibly the worst thing we ever did to our own people outside of slavery & war has to be the Tuskegee Syphilis Study. For this study, which began in 1932, the U.S. Public Health Service began working with the Tuskegee Institute. They wanted to try to find a way to curb the effects of Syphilis. Yet they also wanted to track the progression of the disease to better understand it too. To do this, they went to Macon County, Alabama, and decided to pick 600 poor, illiterate, black male sharecroppers. 399 of them had previously contracted syphilis. However, they did not know they had it.

Sources:
New York Times
New York Post
The Guardian
New York Daily News
Independent
Research Gate
National Institutes of Health
American Central Intelligence Agency
Center for Disease Control
Stanford University
History.com
Britannica
Timeline
United States Holocaust Memorial Museum